منابع مشابه
Retinoids and cancer.
The synt hetic retinoids represent a new class of drugs wh ich a re highly effective in t he treatment of a broad spectrum of dermatologic d isease, including cystic acne, psori asis, and cutaneous di sorders of keratinization [1 3]. Moreover, t he use of synthetic retinoids in cancer prevent ion and therapy fo r both cutaneous and in te rna l t umors is potent ially the most signi ficant clini...
متن کاملUnderstanding Topical Retinoids
Retinoids have been a mainstay treatment in dermatology for over fifty years . They are synthetic compounds derived from vitamin A. Studies have shown that these derivatives help clear comedonaland inflammatory lesions while controlling the bacteria implicated in most types of acne. Originally marketed as Retin A, these topical retinoids have gone through numerous transformations over the years...
متن کاملRetinoids and Bone
Vitamin A (retinol) can be produced in the body by hydrolysis of retinyl esters or reduction of retinal. Liver and eggs, which are good animal sources of vitamin A, contain retinyl esters. Plant sources such as carrots and spinach contain pro-vitamin A carotenoids, which can be cleaved to retinal. Retinal, also called retinaldehyde, is interconvertible with retinol (Fig. 1). Retinal also serves...
متن کاملRetinoids As Teratogens
Vitamin A (retinol) is an essential vitamin in the daily functioning of human beings that helps regulate cellular differentiation [2] of epithelial tissue. Studies have shown that an excess of vitamin A can affect embryonic development and result in teratogenesis, or the production of birth defects [3] in a developing embryo. Excess intake of vitamin A and retinoids by pregnant women often resu...
متن کاملRetinoids in lung development.
The "retinoid revolution" has had considerable impact on research activity in the field of lung development. Postnatal lungs are very sensitive to dietary retinol (R) deprivation. The trachea and the bronchopulmonary tree in R-deficient animals show a striking change in morphology. The columnar epithelium undergoes keratinizing metaplasia, which is reversed when R is supplied. The fetal lung de...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2000
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.87.5.355